How does treanda work

The researchers found that the people who took Venclexta and rituximab had a lower risk of their cancer spreading or getting worse, compared with people who received bendamustine and rituximab. Treanda and Venclexta are both brand-name drugs. Treanda is available as a generic drug called bendamustine. There are currently no generic forms of Venclexta. Brand-name medications usually cost more than generics. According to estimates on WellRx. Like Venclexta above , the drug Zevalin ibritumomab tiuxetan has uses similar to those of Treanda.

Below are examples of these side effects when used to treat B-cell NHL. These lists contain up to 10 of the most common mild side effects that can occur with each drug, or with both Treanda and Zevalin when taken individually. These lists contain examples of serious side effects that can occur with Treanda, with Zevalin, or with both drugs when taken individually.

A boxed warning is the most serious warning from the FDA. Treanda and Zevalin are both brand-name drugs. There are currently no generic forms of Zevalin. Treanda may also be used off-label for other conditions. Treanda is FDA-approved to treat chronic lymphocytic leukemia CLL , a specific type of leukemia that affects lymphocytes. These are a kind of white blood cell. Normal lymphocytes flow through your blood, helping your body fight infections.

As the number of cancerous lymphocytes increases, they start crowding out normal lymphocytes. Treanda works by stopping cells from growing and dividing. This stops cancer cells from expanding and spreading. The drug attacks all multiplying cells in the body, which can cause serious side effects. Specifically, the cancer develops from lymphocytes, which are a kind of white blood cell. Treanda works by keeping cells from growing and dividing. But the rituximab or related treatment stopped working for them.

Everyone in the Treanda study received Treanda. No one received a different medication or a placebo treatment with no active drug. A response meant that their cancer either shrank or disappeared. Half of the people in the study had not had progression of disease at about 9 months. In addition to the uses listed above, Treanda may be used off-label for other purposes. Below are examples of off-label uses for Treanda. However, bendamustine the active drug in Treanda may be used for this purpose according to National Comprehensive Cancer Network guidelines.

A clinical study looked at people with NHL that was indolent or mantle cell. They received one of two treatments:. If you have any questions about the use of bendamustine and Rituxan in treating NHL, talk with your doctor. But the drug may sometimes be used off-label for this condition. In one study , researchers found that a treatment of bendamustine and a drug called brentuximab vedotin was effective in treating Hodgkin lymphoma that had stopped responding to treatment.

If you have any questions about the use of Treanda in treating Hodgkin lymphoma, talk with your doctor. One clinical study looked at people with multiple myeloma. Researchers found that more people who received bendamustine and prednisone achieved complete remission than people who received melphalan and prednisone. If you have any questions about the use of Treanda in treating multiple myeloma, talk with your doctor.

Treanda can interact with several other medications. It can also interact with certain supplements as well as certain foods. Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase the number of side effects or make them more severe. Below is a list of medications that can interact with Treanda. Before taking Treanda, talk with your doctor and pharmacist.

Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Treanda gets metabolized broken down in the body by an enzyme called CYP1A2. Enzymes are proteins that aid chemical changes in your body. Certain medications keep your body from making CYP1A2, so they may stop your body from breaking down Treanda. This can result in the Treanda level in your body becoming too high, which may increase your risk for side effects. Before you take Treanda, ask your doctor if any medications that you use can interact with Treanda.

They may suggest different treatments. However, you should still check with your doctor or pharmacist before using any of these products while taking Treanda. If you have any questions about eating certain foods with Treanda, talk with your doctor.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs. The recommended dose of Treanda for chronic lymphocytic leukemia CLL is mg per meter squared m 2 of body surface area.

Your doctor will determine your body surface area by using your height and weight. The dose will be split between two infusions, which last 30 minutes each. You can receive up to six cycles of Treanda for CLL. If you have side effects from Treanda, your doctor may lower your dose to help you better tolerate the drug.

The dose will be split between two infusions, which last 60 minutes each. You can receive up to eight cycles of Treanda for this type of NHL. The staff will work with you to reschedule you as soon as possible. A medication timer may be useful, too. Treanda is meant to be used as a long-term treatment. As with all medications, the cost of Treanda can vary. To find current prices for Treanda in your area, check out WellRx.

The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. They also induce cell suicide self-death or apoptosis. Chemotherapy drugs that affect cells only when they are dividing are called cell-cycle specific. Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific. The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective.

This is why chemotherapy is typically given in cycles. Chemotherapy is most effective at killing cells that are rapidly dividing. Unfortunately, chemotherapy does not know the difference between the cancerous cells and the normal cells.

The "normal" cells will grow back and be healthy but in the meantime, side effects occur. Different drugs may affect different parts of the body. Treanda is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell-cycle. There are several types of alkylating agents. Tumour lysis syndrome: Bendamustine, like many other cancer medications, causes many cancer cells to be suddenly killed when treatment is first started.

This can overwhelm the body with waste products from the cells. As a result, the body may not be able to keep up with getting rid of all the waste. When this happens, you may have nausea, shortness of breath, cloudy urine, or joint pain. This is called tumour lysis syndrome. Your doctor may prescribe some medications to help your body get rid of the waste products.

Make sure you understand how to use these medications and report any of these signs or symptoms to your doctor immediately. Pregnancy: There is a possibility of birth defects if either the man or woman is taking bendamustine at the time of conception, or if it is taken during pregnancy.

Use effective birth control starting 2 weeks before receiving this medication and for at least 4 weeks after receiving your last dose. If you become pregnant while taking this medication, contact your doctor immediately. Breast-feeding: It is not known if bendamustine passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Women who are using bendamustine are advised to not breast-feed. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children. If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:. An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter non-prescription , and herbal medications that you are taking.

Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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